Neoplasms

Nervous System Diseases

All Conditions

Symptoms and General Pathology

Rare Diseases

Brain Neoplasms

Medulloblastoma

Neuroinflammatory Diseases

Glioma

Neoplasms, Neuroepithelial

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Neoplasms, Glandular and Epithelial

Neoplasms, Nerve Tissue

Inflammation

Neuroepithelioma

Participants who meet the eligibility criteria in the study will receive Translocation Protein (TSPO) Positron Emission Tomography (PET) for longitudinal, quantitative assessment of brain neuroinflammation following whole brain radiation therapy.

Intravenous injection

* Before or within 2 weeks of starting radiation therapy
* Before starting chemotherapy
* 1 year after the start of radiation therapy Timing cont.
* 1.5 to 2 years after the start of radiation therapy

[18F]DPA714

Asim Bag, MD

QARIN 1 is a study of \[18F\]DPA-714 Translocation Protein (TSPO) Positron Emission Tomography (PET) for longitudinal, quantitative assessment of brain neuroinflammation following whole brain radiation therapy. This TSPO PET, uses a radioactive tracer. An optional MRI (magnetic resonance imaging) will also be performed to monitor brain microstructure damages induced by neuroinflammation.

Primary Objectives

* Assessment of temporal and regional variability of uptake of translocator protein (TSPO) positron emission tomography (PET) tracer.
* Regional variability will be assessed in medial temporal lobe, frontal lobe, and in white matter
* Temporal variability will be assessed by scanning each subject four-times: at baseline (before or within 2 weeks of start of radiation therapy), before start of chemotherapy, at 1 year from the initiation of the radiation therapy, and at 1.5-2 years from the initiation of the radiation therapy
* Correlation of radiation dose in specific brain regions with radiation induced neuroinflammation as measured by uptake of TSPO PET tracer.

Exploratory Objectives

* Assessment of radiation-induced brain microstructure injuries (RIBMI) in specific brain regions (medial temporal lobe, frontal lobe, and in white matter) using advanced magnetic resonance imaging (MRI) techniques.
* Association of radiation dose with MRI measures of RIBMI in these specific brain regions.
* Association of PET measures of RIN with MRI measures of RIBMI.
* Association of PET measure of RIN and MRI measures of RIBMI in specific regions of interest (ROI) with specific domain of neuro-cognition. For example, to investigate whether PET measure of RIN and MRI measures of RIBMI in hippocampal ROI have strongest association with episodic memory; whether frontal lobe cortical ROI are associated with attention and executive function.
* Association of a novel MRI based technique for assessment of RIN with TSPO PET.
* Association of the PET and MRI measure of neuroinflammation within 2- years of completion of radiation with delayed cognitive outcome that will be measured at 3, 4 and 5 years from the completion of radiation

The participant will have 4 PET scans using a novel PET tracer that will help the investigators to quantify when and where in brain neuroinflammation happens following radiation therapy. The participant will receive the first PET scan either before your first dose of radiation therapy or within 2 weeks of the start of radiation therapy. The second PET scan will be obtained before starting chemotherapy. The third scan will be after 1 year of treatment.The final scan will be 1 and a half to 2 years after the start of treatment.The scan process will begin an hour or so after the participant has been given tracer by injection. The entire PET scan process lasts about 2 hours.

Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study

Individual participant de-identified datasets containing the variables analyzed in the published article will be made available (related to the study primary or secondary objectives contained in the publication). Supporting documents such as the protocol, statistical analyses plan, and informed consent are available through the CTG website for the specific study. Data used to generate the published article will be made available at the time of article publication. Investigators who seek access to individual level de-identified data will contact the computing team in the Department of Biostatistics (ClinTrialDataRequest@stjude.org) who will respond to the data request.

SUVr values for dorsolateral prefrontal cortex comparing baseline vs. follow up 1

SUVr values for medial prefrontal cortex comparing baseline vs. follow up 1

SUVr values for hippocampus comparing baseline vs. follow up 1.

SUVr values for Corpus callosum comparing baseline vs. follow up 1.

SUVr values for corticospinal tract comparing baseline vs. follow up 1.

SUVr values for superior longitudinal fasciculus comparing baseline vs. follow up 1

SUVr values for dorsolateral prefrontal cortex comparing baseline vs. follow up 2.

SUVr values for medial prefrontal cortex comparing baseline vs. follow up 2.

SUVr values for hippocampus comparing baseline vs. follow up 2.

SUVr values for Corpus callosum comparing baseline vs. follow up 2.

SUVr values for corticospinal tract comparing baseline vs. follow up 2.

SUVr values for superior longitudinal fasciculus comparing baseline vs. follow up 2.

SUVr values for dorsolateral prefrontal cortex comparing baseline vs. follow up 3.

SUVr values for medial prefrontal cortex comparing baseline vs. follow up 3.

SUVr values for hippocampus comparing baseline vs. follow up 3.

SUVr values for Corpus callosum comparing baseline vs. follow up 3

SUVr values for corticospinal tract comparing baseline vs. follow up 3.

SUVr values for superior longitudinal fasciculus comparing baseline vs. follow up 3.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study	NCT05128903	Brain Tumor Medulloblastoma	[18F]DPA714	8 Years - 39 Years	St. Jude Children's Research Hospital
Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study	NCT05128903	Brain Tumor Medulloblastoma	[18F]DPA714	8 Years - 39 Years	St. Jude Children's Research Hospital

Spots Global Cancer Trial Database for [18f]dpa714

Every month we try and update this database with for [18f]dpa714 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for [18f]dpa714

Every month we try and update this database with for [18f]dpa714 cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for [18f]dpa714 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.